‘Turning many to righteousness’ : Religious didacticism in the ›Speculum humanae salvationis‹ and the similitude of the oak tree

In this contribution I shall be interested, among other things, in finding a place for the European phenomenon of the ›Speculum humanae salvationis‹ within German literary history, which will inescapably involve revisiting the unfashionable discussion of date and origins. I also intend to ask about the place of this text in the ‘didactic’ literature of the Middle Ages. Is a religious text structured according to sacred history didactic? Much didactic poetry is in the vernacular: What does it mean that the ›Speculum‹ was composed in Latin? And what place should be accorded to its vernacular reception? The ›Speculum‹ is inscribed within a set of oppositions that would appear to be recurrent in the didactic literature of the later Middle Ages: Latin and vernacular, verse and prose, words and pictures, religious and profane, moral teaching and devotion, clerical and lay. In view of its exceptionally broad transmission in the German lands, both in Latin and in vernacular reworkings, is it possible to describe this text so that it takes a place within a larger picture? In some respects it may stand at a threshold in the history of European didacticism

The structure and dynamics of riverine vegetation in the Umfolozi game reserve

A dissertation Submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, for the Degree of Master of Science. .The cyclone Domoina floods of 1984 were responsible for the large scale destruction and devastation of riverine vegetation in the Umfolozi Game Reserve. This event highlighted the need to gain an understanding af the structure and dynamics of riverine vegetation and to use this knowledge to develop a management strategy directed at the future recovery and maintenance of riverine vegetation in the Umfolozi Game Reserve. (Abbreviation abstract)Andrew Chakane 201

Peptide Co-Agonists for Combined Activation of the APJ and GLP-1 Receptors with Insulinotropic and Satiety Actions Show Potential for Alleviation of Metabolic Dysfunction in Type 2 Diabetes

Stable analogues of the adipokine apelin-13 have shown promising therapeutic potential via APJ receptor activation in isolated β-cells and in animal models of obesity-related diabetes.Incretin mimetics such as exenatide that bind to GLP-1 receptors are well-established Type 2 diabetes treatment options. We developed novel hybrid co-agonist peptide analogues incorporating both exendin-4(1-30) covalently linked to apelin (ELA). The dose-dependent (10−12 to 10−6 M) actions of ELA and component peptides were tested on acute (20 min) insulin secretion from cultured pancreatic BRIN-BD11 β-cells at 5.6 mmol/L glucose. In addition, separate tests were performed in the presence or absence of specific APJ and GLP-1 receptor antagonists. The co-agonist ELA peptide showed markedly greater insulinotropic actions (1.6 to 3.3-fold) than equimolar concentrations of either component peptide alone or in combination (p < 0.001). ELA and related acylated analogues (25 nmol/kg i.p. injection) were also tested on cumulative food intake in trained 21 h-fasted adult mice (n = 8), with food intake measured at 30 min intervals up to 180 min. The ELA co-agonist peptides significantly reduced food intake (3.1-fold by 180 min) in mice (p < 0.001) versus saline treated controls. ELA peptides showed marked improvements in both insulin secretion and appetite control, raising interest in their therapeutic potentia

Promoting diversity among SMEs using a dynamic interdependence approach

This paper explores the question of whether there is an ethical business case for Small and Medium Sized Enterprises (SMEs) employing a more diverse workforce with Regan and Stanley (2003: p.v) arguing that employers should look beyond their legal obligations in respect of disadvantaged groups. What attitudes do SME employers have to such proposals, what are their current practices and how can they be supported to meet skills shortages through employing a more diverse workforce? The primary data was derived from focus group sessions with local SMEs and interviews with the procurement managers of large employers in Southampton. Examples of good practice in the employment policies of SMEs and business benefits are discussed in relation to the literature on inclusion strategies for disadvantaged groups. The feasibility of using supply chains to encourage employment diversity in SMEs is evaluated. In concluding this paper reflects on how Southampton’s labour market intelligence capability and the capacity of local organisations to deliver effective support services to businesses and to individuals could be built. Finally, the paper initiates discussion on the feasibility of addressing low economic activity and participation rates among disadvantaged individuals and communities

Model Based Definition: Finally, the Engineering Drawing Killer?

The Engineering drawing has stood as the universal method of translating design intent since the first standard was formalized in 1927 as BS308. Further development of national and international standards has been informed by advances in CADCAM technology and the need for transfer of complex yet unambiguous definition between organisations. The emergence of model based definition (MBD) has driven a new workflow where the engineering drawing is no longer required. Instead, the dataset includes semantic, machine readable, tolerancing of surfaces and features for integration into manufacturing and metrology procedures. Despite the advantages of MBD, it has been largely ignored in UK Higher Education. However MBD is the ideal method for teaching and learning geometrical tolerancing since it ignores the theoretically exact dimensions and housekeeping, concentrating on the functional limits. Further, it utilises the 3D workspace that students are increasingly familiar with

Revising Payment for Ecosystem Services in the Light of Stewardship: The Need for a Legal Framework

Since the Millennium Ecosystem Assessment (MEA) highlighted the importance of ecosystem services for human well-being, the payments for such services have increasingly been drawing the attention of governments, the private sector and academia. Nonetheless, there is not yet a specific legal framework which is able to capture the complexity of managing natural resources and, at the same time, deal with the numerous drawbacks that have been identified by critics, who are opposed to using financialisation of the environment as a tool. This paper, after briefly summarizing some of the main features and criticisms of the Payment for Ecosystem Services (PES), will critically assess the understanding of property rights over natural resources as stewardship, rather than as entitlement, because this interpretation is more coherent with the inherent characteristics of natural resources and, consequently, of ecosystem services. The novel usage of a stewardship dimension to property rights underlines the necessity for a legal framework for PES, constituted by “property-liability rules”

Help-seeking for genitourinary symptoms: a mixed methods study from Britain’s Third National Survey of Sexual Attitudes and Lifestyles (Natsal-3)

Objectives: Quantify non-attendance at sexual health clinics and explore help-seeking strategies for genitourinary symptoms. Design: Sequential mixed methods using survey data and semistructured interviews. Setting: General population in Britain. Participants: 1403 participants (1182 women) from Britain’s Third National Survey of Sexual Attitudes and Lifestyles (Natsal-3; undertaken 2010–2012), aged 16–44 years who experienced specific genitourinary symptoms (past 4 weeks), of whom 27 (16 women) who reported they had never attended a sexual health clinic also participated in semistructured interviews, conducted May 2014–March 2015. Primary and secondary outcome measures: From survey data, non-attendance at sexual health clinic (past year) and preferred service for STI care; semistructured interview domains were STI social representations, symptom experiences, help-seeking responses and STI stigma. Results: Most women (85.9% (95% CI 83.7 to 87.9)) and men (87.6% (95% CI 82.3 to 91.5)) who reported genitourinary symptoms in Natsal-3 had not attended a sexual health clinic in the past year. Around half of these participants cited general practice (GP) as their preferred hypothetical service for STI care (women: 58.5% (95% CI 55.2% to 61.6%); men: 54.3% (95% CI 47.1% to 61.3%)). Semistructured interviews elucidated four main responses to symptoms: not seeking healthcare, seeking information to self-diagnose and self-treat, seeking care at non-specialist services and seeking care at sexual health clinics. Collectively, responses suggested individuals sought to gain control over their symptoms, and they prioritised emotional reassurance over accessing medical expertise. Integrating survey and interview data strengthened the evidence that participants preferred their general practitioner for STI care and extended understanding of help-seeking strategies. Conclusions: Help-seeking is important to access appropriate healthcare for genitourinary symptoms. Most participants did not attend a sexual health clinic but sought help from other sources. This study supports current service provision options in Britain, facilitating individual autonomy about where to seek help

Aggregation chimeras provide evidence of in vivo intercellular correction in ovine CLN6 neuronal ceroid lipofuscinosis (Batten disease)

The neuronal ceroid lipofuscinoses (NCLs; Batten disease) are fatal, mainly childhood, inherited neurodegenerative lysosomal storage diseases. Sheep affected with a CLN6 form display progressive regionally defined glial activation and subsequent neurodegeneration, indicating that neuroinflammation may be causative of pathogenesis. In this study, aggregation chimeras were generated from homozygous unaffected normal and CLN6 affected sheep embryos, resulting in seven chimeric animals with varied proportions of normal to affected cells. These sheep were classified as affected-like, recovering-like or normal-like, based on their cell-genotype ratios and their clinical and neuropathological profiles. Neuropathological examination of the affected-like animals revealed intense glial activation, prominent storage body accumulation and severe neurodegeneration within all cortical brain regions, along with vision loss and decreasing intracranial volumes and cortical thicknesses consistent with ovine CLN6 disease. In contrast, intercellular communication affecting pathology was evident at both the gross and histological level in the normal-like and recovering-like chimeras, resulting in a lack of glial activation and rare storage body accumulation in only a few cells. Initial intracranial volumes of the recovering-like chimeras were below normal but progressively recovered to about normal by two years of age. All had normal cortical thicknesses, and none went blind. Extended neurogenesis was evident in the brains of all the chimeras. This study indicates that although CLN6 is a membrane bound protein, the consequent defect is not cell intrinsic. The lack of glial activation and inflammatory responses in the normal-like and recovering-like chimeras indicate that newly generated cells are borne into a microenvironment conducive to maturation and survival

Childhood fantasy play relates to adult socio‐emotional competence

Childhood fantasy play and creation of imaginary companions are thought to confer socio‐emotional benefits in children, but little is known about how they relate to socio‐emotional competence in adulthood. A total of 341 adults (81 males) aged 18 and above (M = 31.47, SD = 12.62) completed an online survey examining their fantasy play as a child, their childhood imaginary companion status, and their adult socio‐emotional competence. Adults who reported higher levels of childhood fantasy play were found to be significantly more prosocial, empathetic, and emotionally intelligent than their counterparts after controlling for demographic factors. Recall of a childhood imaginary companion, however, was significantly related only to higher scores for perspective‐taking and did not explain unique variance in any adult competence measure. Findings suggest that engagement in fantasy play during childhood may be a precursor to later socio‐emotional competence, while benefits previously associated with imaginary companions specifically may not extend into adulthood